Non-genomic Action of Sex Steroid Hormones and Cardiac Repolarization
نویسندگان
چکیده
منابع مشابه
Non-genomic action of sex steroid hormones and cardiac repolarization.
Gender differences play a major role in the manifestation of cardiovascular disease including cardiac arrhythmias. In particular, female sex is an independent risk factor for development of torsade de pointes (TdP) arrhythmias not only in congenital long QT syndromes but also in acquired long QT syndromes which occur as adverse effects of existing drugs. Recent clinical and experimental studies...
متن کاملNon-genomic actions of sex steroid hormones.
Steroid hormone receptors have been traditionally considered to act via the regulation of transcriptional processes, involving nuclear translocation and binding to specific response elements, and ultimately leading to regulation of gene expression. However, novel non-transcriptional mechanisms of signal transduction through steroid hormone receptors have been identified. These so-called 'non-ge...
متن کاملSex, hormones, and repolarization.
There is increased awareness of the impact of gender and gonadal steroids on human cardiac rhythm and arrhythmias; e.g., drugs that prolong repolarization induce torsades de pointes (TdP) more frequently in women than men; female gender is an independent risk factor for syncope and sudden death in the congenital long QT syndrome; and the higher propensity toward arrhythmia in normal females is ...
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In 1950, Frieden and Hisaw (2) described a method for the isolation of relaxin from the ovaries of pregnant sows. This method, which involved extraction of ground whole ovaries with 5 per cent aqueous SaCl, fractionation with ethanol, and finally precipitation with acetone, afforded good yields (200 to 250 GPU’ of relaxin per gm. of fresh tissue), and material of saCsfactory potency (30 to 90 G...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2013
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.b212021